申論題

(摘錄自Nutrients202012:2422)

 Abstract: Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to dentify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assess sment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (rangeltotal) Physiotherapy Evidence Database (PEDro) score of 7 (6-9) out of 10, respectively. Five RCTs that cnrolled patients who anderwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p ＜ 0.00001), pain (SMD = 1.36, p ＜ 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strengih, and functional outcomes and reduces pain Ain older aduits with lower-limb OA, particularly in those who have undergone total joint replacement.