112年 - 112 國立成功大學碩士班招生考試_口腔醫學研究所：生物化學#118641

科目：研究所、轉學考(插大)◆生物化學 | 年份：112年 | 選擇題數：20 | 申論題數：0

試卷資訊

所屬科目：研究所、轉學考(插大)◆生物化學

選擇題 (20)

1. According to the following data, what is the Km of the enzyme to its substrate? (A) 0.2 mM (B) 0.5 mM (C) 1.0mM (D) 5.0mM (E) 50.0 mM

2.The affinities of hexokinase to glucose, fructose, galactose and.mannose are 0.08, 6.7, 15, and 0.13 mM, respectively. Based on these data, which monosaccharide is more likely to be phosphorylated by this hexokinase? (A) Glucose (B) Fructose (C) Galactose (D) Mannose

3. Which residues in proteins are common sites for phosphorylation? (A) Serine, Histidine (B) Threonine, Tyrosine (C) Threonine, Lysine (D) Serine, Aspartate

4. Which ofthe following features protect mRNA from premature degradation by cellular exonucleases? (A) poly( A ) tail (B) 5'-methylguanosine cap (C) introns (D) Both AandB (E) All of the above

5. 5-Fluorouracil (5-FU) is a cancer chemotherapy drug whose main mode of action is to block the synthesis of which of the following materials necessary for DNA replication? (A) dTTP (B) dATP (C) dCTP (D) 'dGTP (E) All of the above

6.What is the order of protein, DNA and mRNA retention time in the cell from longest to shortest? (A) DNA＞mRNA ＞ protein (B) DNA ＞ protein＞mRNA (C) protein＞DNA＞mRNA (D) protein ＞mRNA＞ DNA (E) mRNA＞ protein＞ DNA

7. Which of the following structures is produced by the assembly of the eight subunits of histones? (A) Centromere (B) Condensin (C) Nucleosome (D) Telomere (E) None of above

8. Which of the following is responsible for the epigenetic regulation of gene expression? (B) Mutations of CpG islands (C) Acetylation of histone (D) A andC (E) All of the above (A) Methylation of cytosine

9. Which of the following DNA regions is most likely to be the target of methylation? (A) Telomere (B) GC dinucleotides (C) Mutated DNA (D) TATA box regions (E) Trinucleotide expansion regions

10. What is the maximum number of 100 amino acid long polypeptides that could be made? (A) 20 (B) 20¹⁰¹(C) 100²⁰(D) 20¹⁰⁰(E) None of above

11. What is the main source of blood sugar after fasting for eight hours? (A) dietary carbohydrates (B) Glycerol from adipocytes (C) Glycogen degradation in the liver (D) Glycogen degradation in muscle (E) Protein degradation in muscle

12. Gluconeogenesis and glycogenolysis share which of the following enzymes? (A) Fructose 1,6-bisphosphatase (B) Glucose 6-phosphatase (C) Glycogen phosphorylase (D) Pyruvate carboxylase (E) Pyruvate kinase

13. Which of the following intracellular locations is the site of beta-oxidation of very-long-chain fatty acids? (A) Cytoplasm (B) Endoplasmic reticulum (C) Mitochondrial matrix (D) Mitochondrial in-membrane space (E) Peroxisomes

14. In a double stranded conformation, the following two DNA sequences which have a lower melting temperature? (A) GGCATTATGAATCGG (B) GGCGTTATGAATCGG (C) GGCGTCATGAATCGG (D) GGCGTCCTGAATCGG (E) GGCGTCCGGAATCGG

15.Melanin is the pigment of the hair, skin and iris of the eyes and is synthesized' in melanocytes. Which of the following amino acids is the precursor of melanin synthesis? (A) Arginine (B) Glycine (C) Histidine (D) Tryptophan (E) Tyrosine

16. Which of the following tripeptides would be most likely to be soluble in a hydrophilic solution like phosphate buffer? (A) N-phenylalanine-alanine-glycine-c (B) N-glutamate-aspartate-glycine-C (C) N-proline-phenylalanine-leucine-C (D) N-arginine-lysine-proline-C (E) N-leucine-alanine-lysine-C

17. Prostaglandin synthesis requires eicosanoids, which of the following fatty acids are precursors for eicosanoid biosynthesis? (A) Arachidonic acid (B) Oleic acid (C) Palmitic acid (D) Stearic acid (E) None of above

18. Which of the following laboratory tests are best for detecting a trisomy of chromosome 21? (A) Chromosomal microarray (B)Comparative genomic hybridization (C) G-banding (D) SNP microarray (E) All of above

19. Which of the following complexes contains DNA helicase, DNA topoisomerase, DNA polymerase, and RNA primase? (A) Minichromosome maintenance complex (MCM) (B) Mismatch repair complex (C) Origin of replication complex (ORC) (D) Replisome complex (E) All of above

20. The addition of RNA polymerase II to the DNA template sequence 5' -GCTACT-3' will synthesize which of the following products? (A) 5'-CGAUGA-3' (B) 5'-CGATGA-3' (C) 5'-AGUAGC-3' (D) 5'-AGTAGC-3' (E) 5'-GCUACU-3'

申論題 (0)