複選題10. Which of the following statements regarding "Signaling Pathways" are CORRECT? (A) Most genes regulated by PKA contain a cis-acting DNA sequence that binds to the phosphorylated CREB (B) Phosphorylation of ẞ-catenin by GSK3 kinase can increase the B-catenin protein level and stimulate the Wnt pathway activity (C) Protein kinase B is activated at the plasma membrane, by the activating kinase PDK1 (D) Ras is a guanine nucleotide exchange factor, which is inactive when bound with GDP (E) The nuclear hormone receptor can be activated by binding with the lipid soluble hormone, and then move from cytosol to nucleus for transcription