複選題
60.會影響鈣離子在肌纖維內的分布，而具骨骼肌鬆弛作用的藥物是：

(A)quinine
(B)hydrastine
(C)tubocurarine chloride
(D)strychnine

答案：登入後查看
統計： A(472), B(108), C(1097), D(421), E(0) #3488328

詳解 (共 4 筆)

#6559574

Quinine (0.5-5.0 mM) induced a strong relaxation of rat ileal smooth muscle. This relaxation, however, was accompanied by a significant stimulation of Ca45 efflux from the muscles.

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Ref: https://www.sciencedirect.com/science/article/abs/pii/0306362377900118#:~:text=These%20results%20are%20consistent%20with,of%20extracellular%20calcium%20during%20contraction.
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因為我也錯這題，因此想和各位分享：
Tubocurarine, a non-depolarizing neuromuscular blocker, does not directly interact with calcium within muscle cells to cause muscle relaxation. Instead, it acts by blocking the action of acetylcholine (ACh) at the neuromuscular junction, preventing muscle contraction. Calcium is essential for muscle contraction, but tubocurarine's mechanism involves preventing the signal (ACh) that triggers calcium release, rather than directly affecting calcium's role within the muscle cell. 
Ref: Google AI
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抱歉開啟懸賞，但懸賞期間不開此功能的話，內容會跑到筆記區，等十天後我會將其解除，請見諒。
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#6566242
[一次通過還願中，主要針對題目本身進行解析或提供考試時的解題想法]
[若解析不夠詳盡/侵害權益，煩請聯繫修正/刪除]
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由衷好奇這題沒有選Tubocurarine chloride的人有多少= = 
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(A) quinine(Quinoline alkaloids)
→原文書資料如下：Quinine has a skeletal fractory peroid by direct action on the muscle fiber, decreasing the excitability of the motor end-plate by a curariform action, and affecting the distribution of calcium within the muscle fiber.
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(B) hydrastine(Isoquinoline alkaloids-phthalideisoquinoline)
→原文書資料如下：The hydrastis alkaloids, hydrastine and berberine, are used as astringents(收斂劑) in inflammation of the mucous membranes.
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(C) tubocurarine chloride(Isoquinoline alkaloids-Benzylisoquinoline)
→原文書資料如下：Tubocurarine chloride is employed as a skeletal muscle relaxant to secure muscle relaxation in surgical procedures without deep anesthesia. It is also used to control convulsions of strychnine poisoning and of tetanus; ...[是肌肉鬆弛劑，但是沒有提到影響鈣離子分布]
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(D) strychnine(Indole alkaloids)
→原文書資料如下：Strychnine is interesting pharmacologically and is a valuable tool in physiologic and neuroanatomic research. Is ia extremely toxic, functioning as a central stimulant.
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#6633584

(A)Quinine(奎寧)可干擾骨骼肌纖維內的鈣離子分布，減少收縮力，有骨骼肌鬆弛作用。


(C)箭毒鹼也給分
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#6632012
A、C都給分了
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