複選題

72. Ketone bodies are overproduced in diabetes and during starvation. Which of the following metabolites is not an intermediate from two molecules of acetyl-CoA to acetone?
(A) Acetoacetyl-CoA
(B) β-hydroxy-β-methylglutaryl-CoA
(C) Acetoacetate
(D) β-hydroxybutyrate
(E) CoA-SH

.

68. Gluconeogenesis synthesizes glucose, while glycolysis catabolizes glucose. It is evident that gluconeogenesis and glycolysis must be controlled in reciprocal fashion. Which of the following enzymes for glycolysis are not used in the gluconeogenic pathway?①Hexokinase②Phosphofructokinase③Phosphoglycerate kinase ④Triosephosphate isomerase⑤Pyruvate kinase (A)①②③(B)①②④(C)①②⑤(D)②③⑤(E)③④⑤

69. The potent allosteric activator for phosphofructokinase-1 in glycolysis is _______.(A) fructose 1,6-bisphosphate (B) citrate (C) ATP (D) fructose 2,6-bisphosphate (E) acetyl-CoA

70. Which of the following compounds can prevent electron transfer from the Fe-S center to ubiquinone in oxidative phosphorylation process? (A) Rotenone(B) Cyanide(C) 2,4-Dintrophenol (D) Oligomycin(E) Valinomycin 

71. Which of the following fatty acids cannot be synthesized by human?(A) Linoleate [18:2(Δ9,12)] (B) Stearate (18:0) (C) Oleate [18:1(Δ9 )] (D) Palmitoleate [16:1(Δ9 )] (E) Arachidonate [20:4(Δ5,8,11,14)]

73. Which is not involved in fatty acid oxidation? (A) Starts from carboxylate end (B) Acyl-CoA dehydrogenase (C) Acyl-CoA hydratase (D) β-hydroxyacyl-CoA dehydrogenase (E) Acyl-CoA acetyltransferase

74. Which is the potent inhibitor of carnitine acyltransferase I? (A) Carnitine (B) Acetyl-CoA (C) Malonyl-CoA (D) Succinyl-CoA (E) Fumarate

75. Flippases are enzymes that flip _______. (A) phospholipids across to the other side of a membrane (B) cholesterol from one organelle to another (C) protons across to the other side of a membrane (D) D-glucose to L-glucose (E) L-form amino acids to D-form amino acids

 76. Degradation of amino acids can produce the precursors that are used to synthesize glucose or convert to ketone bodies. Which of the following amino acids can convert into precursors for the synthesis of glucose? 1. Leucine2.Lysine3. Cysteine4. Asparagine5. Methionine (A)123 (B) 124(C)234(D)245 (E) 345

77. A deficiency of branched chain α-keto acid dehydrogenease complex causes the defect in metabolism of amino acids. The accumulation of α-keto acid in urine leads to maple syrup urine disease. Which of the following amino acids are metabolized by α-keto acid dehydrogenease complex?            1.Methionine2.Leucine3.Isoleucine4.Valine5.Alanine (A)125(B)135(C)234(D)245(E)345

78. Defect in metabolism of phenylalanine causes phenylketounia and alkaptonuria. Which of the following statements are correct? ① A person with phenylketonuria will convert phenylalanine to phenylpyruvate. ② A person suffering from phenylketonuria on consumption food containing high phenylalanine may lead to the accumulation of tyrosine. ③ A person with phenylketonuria is advised not to consume aspartame.④ Alkaptonuria is due to defect in phenylalanine hydroxylase. ⑤ A person suffering from phenylketonuria on consumption food containing high phenylalanine may lead to the accumulation of acetoacetyl-CoA. (A)①② (B)①③ (C)①④ (D)②③ (E)②⑤