11. How do cells distinguish between estrogen and testosterone? (A) Only male cells respond to testosterone and female cells respond to estrogen. (B) Estrogen is hydrophilic and binds to surface receptors, while testosterone is hydrophobic and binds to internal receptors. (C)Estrogen and testosterone have the same basic structures, but different side chains that are easily distinguished by their individual receptors. (D) Estrogen and testosterone have similar functional groups but different basic structures that are easily distinguished by their individual receptors.