12. Which of the following statements is true for gene transcription in the eukaryotes?(A) Tfg2 is the second largest subunit of TFIIF and is homologous to bacterial alpha-subunit of RNA polymerase.(B) Mediator is a collection of proteins that is a part of most RNA polymerase II preinitiation complexes and is not required for transcription initiation, but is required for activated transcription.(C) TFIIIA is a general transcription factor for RNA polymerase III and contains 9 zinc finger structures in which one finger containing 6 cysteines to coordinate 2 zinc ions.(D) In the absence of ligand, the thyroid hormone receptor exists as an inactive form in cytoplasm complexed with heat shock protein 90.(E) Silencers are DNA-binding proteins that can cause strong bending in DNA.