20. Patent Foramen Ovale (PFO), also known as a Hole In The Heart. Which of the following statements about PFO is Not true? (A) In the womb, the blood flows from the high-pressure right side of the heart to the lower-pressure left side keeps the foramen ovale open. (B) At birth, the reversal of pressure gradients caused by the clamping of the placenta could physiologically cause the foramen ovale to snap closed. (C) In a heart with PFO, venous blood leaks from the right atrium into the left atrium, then out to the body, bypassing the pulmonary circulation. (D) PFO is a condition with modifiable and non-modifiable risk factors. (E) Around 25% of the general population has PFO and is typically asymptomatic.