22. Which of the following statements about the urea cycle is correct? (A) The urea cycle begins with ornithine transcarbamylase (OTC), which transfers a carbamoyl group from carbamoyl-CoA to ornithine within the mitochondrial matrix. (B) The nitrogens in urea originate from two sources: one nitrogen comes from ammonia (NH3), and the other nitrogen comes from asparagine. (C) Citrulline is synthesized from pyruvate during the urea cycle and acts as a direct precursor for urea formation in the cytoplasm. (D) The urea cycle is tightly linked to the TCA cycle through fumarate, which is produced in the cytoplasm and can be recycled directly back into the TCA cycle. (E) The urea cycle produces urea as its final product, which is transported from the liver to the kidneys for excretion in the urine.