試題詳解

22.The 2019 Nobel Prize in Physiology or Medicine was awarded to three scientists for discovering hypoxia-ind transcription factor that regulates gene expression in response to decreases in cellular oxygenation. Unde n, HIF1a-HIF 1β heterodimer bonds to target genes' HRE (hypoxia-tesponse element), leading to gen ygen condition, HIF 1a is hydroxylated in two ( residues and recruits E3 () ligase for protein deg the three blanks?
(A) Activation, proline, ubiquitin.
(B) Inhibition, proline, ubiquitin.
(C) Activation, histidine, ubiquitin.
(D) Inhibition, histidine, SUMO.
(E) Activation, proline, SUMO.