25 下列抗血小板之藥物中，何者會產生嗜中性球減少症之嚴重副作用？
(A) Aspirin
(B) Dipyridamole
(C) Eptifibatide
(D) Ticlopidine

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統計： A(22), B(79), C(83), D(302), E(0) #417871

詳解 (共 4 筆)

#1195307
(C) Eptifibatide :阻斷血小板之 glycoprotein IIb/IIIa 接受器
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0
#788760
Ticlopidine can cause life-threatening hematological adverse reactions, including neutropenia/agranulocytosis, thrombotic thrombocytopenic purpura (TTP) and aplastic anemia.
Ticlopidine hydrochloride, after oral ingestion, interferes with platelet membrane function by inhibiting ADP-induced platelet-fibrinogen binding and subsequent platelet-platelet interactions.
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0
#4400467
Clopidogrel的機轉作用在ADP receptor, P2Y12受體上。 因為副作用顆粒白血球減少、再生不良性貧血、血小板減少的關係已經較少用的Ticlopidine，也是prodrug，須經代謝(CYP3A4)才能作用，作用於ADP receptor。
3
0
#5772274
ADP-R抑制劑Ticlopidine ...
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0