試題詳解

25. Dr. Roger Komberg (Stanford University) used structural basis to reveal the mechanism of        nucleotide selection       in the posttranslocation state of eukaryotic RNA polymerase II. Which of the following statement is       not true      ?
(A) The study reveals two distinct nucleotide-binding sites, the E and A sites, at the active center of RNA polymerase II
(B) The E site is the location where incoming nucleotide first encounters
(C) The A site is the location where phosphodiester bonds form
(D) Rotation of nucleotide between the E and A sites may be helpful for base specificity
(E) Rotation of nucleotide between the E and A sites may be affect the specificity for deoxyribonucleotides as opposed to ribonucleotides