30 Thioperamide 可以較具選擇性的拮抗下列何種受體的作用？
(A) 5-HT 2
(B)H 2
(C) 5-HT 3
(D)H 3

答案：登入後查看
統計： A(570), B(374), C(644), D(939), E(0) #417344

詳解 (共 5 筆)

#1239826
Histamine作用在H3受器上可抑制histamine之釋放，而H3受器拮抗劑 thioperamide可使histamine釋放出來而達到減少食物的攝取效果，但此效果會被H1受器拮抗劑 chlorpheniramine所阻斷。
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#2561648

23 下列那一種藥物是Histamine H 3 receptors 的拮抗劑？ 
(A) Thioperamide 
(B) α-methylhistamine 
(C) Imetit 
(D) Immepip 

編輯私有筆記及自訂標籤
答案：A 
難度：困難
統計： A(13),B(2),C(11),D(1),E(0) #659282
個人： 尚未作答
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#4320261
H3 agonist基本結構都為R-al...
(共 256 字，隱藏中）
前往觀看
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#694366
H 3 &H 4
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#914074

This receptor has been proposed as a target for treating sleep disorders.[9] The receptor has also been proposed as a target for treating neuropathic pain.[10]

Because of its ability to modulate other neurotransmitters, H3 receptor ligands are being investigated for the treatment of numerous neurological conditions, including obesity (because of the histamine/orexinergic system interaction), movement disorders (because of H3 receptor-modulation of dopamine and GABA in the basal ganglia), schizophrenia and ADHD (again because of dopamine modulation) and research is underway to determine whether H3 receptor ligands could be useful in modulating wakefulness (because of effects on noradrenaline, glutamate and histamine).[11]

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