試題詳解

36. Regarding the peripheral mechanisms of cutaneous nociception, which of the following statement is least likely:
(A) Following a cutaneous injury, primary hyperalgesia develops at the site of injury, which is called sensitization. This sensitization is due to the local release of inflammatory mediators such as interleukins (IL-10) and prostaglandin E1.
(B) Secondary hyperalgesia was induced in the surrounding uninjured skin, which is due to sensitization of neurons in the central nervous system.
(C)hen nerves are severed, spontaneous activity and ectopic mechanical, thermal, and chemical sensitivity develop in the injured nociceptors.
(D) The properties of nearby, uninjured nociceptors are also changed.
(E) In both injured and uninjured nociceptors, responsiveness to adrenergic agents can develop, which may account for involvement of the sympathetic nervous system in certain forms of neuropathic pain.