38. (A) This means the body's cells do not respond effectively to insulin, the hormone responsible for moving glucose (sugar) from the bloodstream into the cells for energy.(B) Management in 2026 emphasizes early detection during the "prediabetes" stage, where blood sugar is elevated but not yet at diabetic levels. (C) However, 2026 has seen a shift toward P4 Medicine: Predictive, Preventive, Personalized, and Participatory. (D) Untreated hyperglycemia causes systemic damage.