4. Regions flanking centromeres in chromosomes are rich in:
(A) unique sequence DNA and euchromatin
(B) unique sequence DNA and heterochromatin
(C) satellite DNA and euchromatin
(D) satellite DNA and heterochromatin

5. Which of the following is a false statement about telomerase? (A) dCTP and dATP are not substrates of telomerase. (B) The RNA component of telomerase serves as the template for telomere synthesis. (C) Telomerase uses the 5'-end of the telomere to prime telomere synthesis (D) The protein component of telomerase is a reverse transcriptase.

6. The transient covalent modification of the N-terminal tails of the core histone proteins: (A) facilitates the process of transcription and DNA replication (B) disrupts nucleosome/DNA interaction by the introduction of a net positive charge on the nucleosomes. (C) is specific for the R groups of valine, isoleucine and alanine. (D) exclusively involve the histone tails of H2A and H2B. (E) answers A and B are correct

7. Which of the following features are common to essentially all (prokaryotic, eukaryotic, viral) replication origins? (A) Origin sequences have inverted repeats that form stable secondary structures for assembly of the replication apparatus. (B) Origins are unique DNA segments that often contain multiple short repeated sequences involved in binding to replication proteins. (C) DNA polymerase is able to recognize promoter-like sequences at the replication origins. (D) The origin-flanking sequences are G-C rich to stabilize the DNA-protein initiation complex.

8. At normal growth temperature (37°C), how long does it take for complete replication of the (E) coli chromosome? (A) 20 minutes (B) 40 minutes (C) 60 minutes (D) 90 minutes

9. Transfer of the F factor from one bacterial cell to another occurs as: (A) Single-stranded DNA generated by rolling circle replication in the donor cell. (B) Single-stranded DNA generated by unidirectional replication in the donor cell. (C) Double-stranded DNA generated by rolling circle replication in the donor cell. (D) Double-stranded DNA generated by unidirectional replication in the donor cell.

10. In September 2016, a baby was born with the DNA of two women (the mother and a donor) and a man (the father). The baby was conceived through the technique of so called "three-parent in vitro fertilization". Which of the following statement is correct: (A) The three parents provided DNA from nucleus, peroxisome and mitochondrion, respectively. (B) The nucleus was removed from the egg cell of a donor and the de-nucleated egg cell was then injected with the nuclear DNA from the mother's egg cell. (C) The technique was used because the mother has a genetic disease due to a mutation in the nuclear DNA. (D) The sperm provided the mitochondrial DNA.

11. What two proteins are required for unwinding duplex DNA and stabilizing the resulting single strands? (A) DNA primase and helicase (B) DNA primase and replicase (C) Replicase and single-stranded DNA binding protein (D) Helicase and single-stranded DNA binding protein

12. The (E) coli chromosome replicates bidirectionally, this means there: (A) are two replication origins on the bacterial chromosome. (B) are two daughter duplexes formed after replication of the DNA. (C) are two replication forks established that move in opposite directions. (D) is replication of both a leading strand and a lagging strand.

13. An (E) coli mutation that greatly reduces the 3'-5' exonuclease activity of DNA polymerase I would result in: (A) cell death (B) very little or no effect on cell viability (C) a significantly decreased mutation rate (D) a significantly increased mutation rate

14. What type of DNA structure is needed for initiation of homologous DNA recombination? (A) broken, blunt-ended DNA (B) a free 5' single-stranded region (C) a free 3' single-stranded region (D) any of the above

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