4.__________ he was ill for many years , he was always cheerful.
(A) Although
(B) In spite of
(C) However
(D) Nevertheless

˙Although/Even though

1.      Clause, although/even though clause

2.      Although/Even though clause, clause

˙Despite/In spite of + N.

Ex: Although/ Even though it was raining, I still went to the beach.

Ex: Despite/In spite of the rain, I still went to the beach.

˙However/Nevertheless

  1^st sentence. H/N, 2^nd sentence.

Ex: I eat chocolate. However, /Nevertheless ,I am allergic.

= I am allergic. However, /Nevertheless ,I eat chocolate.

˙but/,yet

  Clause but/, yetclause

Ex:Originally, you could move to next leavebut/, yetyou failed the test.

=You failed the testbut/, yetyou could move to next level originally.