阿摩線上測驗
41.林太太有糖尿病腎病變，血清肌酸酐為2.4 mg/dL，併用glyburide和metformin控制血糖不佳，則下列處置何者正確？
(A)提高metformin劑量
(B)加上glimepiride
(C)停用metformin並加上glimepiride
(D)停用metformin並加上sitagliptin
答案：登入後查看
統計： A(61), B(65), C(337), D(2027), E(0) #408145
統計： A(61), B(65), C(337), D(2027), E(0) #408145
詳解 (共 9 筆)
神蓉世
#969852
SUs 重 糖 肝
meglitinide 重 糖
TZD 重 肝
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Bryan
#882145
64.下列那種降血糖藥品屬於dipeptidyl peptidase-4（DPP-4）抑制劑，可以刺激胰島素分泌並抑制升糖素（glucagon）？
(A)Pioglitazone
(B)Pramlintide
(C)Repaglinide
(D)Sitagliptin
(A)Pioglitazone
(B)Pramlintide
(C)Repaglinide
(D)Sitagliptin
答案：D
難度：簡單
難度：簡單
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2
Bryan
#849924
Metformin 避免用於腎功能不佳者，女性肌酸酐濃度>1.4mg/dl,男性>1.5
(C)Glyburide 和Glimepiride 同屬於第二代Sulfonylurea
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HUSpiTLE
#3419652
sitagliptin（DPP4 inhibitor）：
Metabolism （肝）
Metabolism by CYP3A4 and, to a lesser degree, CYP2C8 is a minor pathway in the Cl of sitagliptin.
Elimination （主要為腎）
Terminal t ½ is approximately 12.4 h. Approximately 13% is excreted in feces and 87% in urine via active tubular secretion (79% as unchanged drug). Sitagliptin is a substrate for organic anion transport.
副作用：鼻咽炎、上呼吸道感染、腹瀉、噁心和頭痛。
7
1
Bryan
#852638
Sitagliptin is an oral antihyperglycemic of the dipeptidyl peptidase-4 inhibitor class. This enzyme-inhibiting drug is used either alone or in combination with other oral antihyperglycemic agents for treatment of diabetes mellitus type 2. The benefit of this medicine is its fewer side effects in the control of blood glucose values. While safety is its advantage, efficacy is often challenged as it is often recommended to be combined with other agents such as metformin.
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