42. A population of 10,000 diploid organisms shows genotype frequencies that initially conform to Hardy–Weinberg expectations. Over the next generation, which of the following scenarios would be expected to produce the largest deviation from Hardy–Weinberg genotype proportions in a single generation? (A) A 1% migration rate from a genetically similar neighboring population (B) Mild inbreeding with an inbreeding coefficient F = 0.05 (C) Occasional mutation at a rate of 10⁻⁶ per allele per generation (D) A temporary reduction of population size to 5,000 individuals (E) Heterozygote disadvantage reducing heterozygote fitness by 50%