47.What is the primary inhibition mechanism of antimycin on oxidative phosphorylation, and what are the consequences?
(A) Inhibition of complex Ⅰ, leading to decreased electron transport and reduced ATP production.
(B) Inhibition of complex Ⅱ causing disruption in the citric acid cycle and impaired generation of reducing equivalents.
(C) Inhibition of complexⅢ, resulting in the blockade of electron transfer and a decrease in the proton motive force.
(D) Inhibition of ATP synthase, preventing the conversion of the proton motive force into ATP synthesis.
(E) Inhibition of complex TV, leading to the disruption of the final step in the electron transport chain and a decrease in oxygen consumption.

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統計： A(1), B(3), C(12), D(1), E(0) #3236580

詳解 (共 1 筆)

#6233636

Antimycin的主要作用位置：

Antimycin作用於電子傳遞鏈 時,它會抑制Complex III。這個抑制作用會阻止電子從 細胞色素b（cytb）傳遞到細胞色素c1（cytc1），也就是說Antimycin A通過與複合體III的Qi位 點結合,阻斷了細胞色素b（cytb）和細胞色素c1（cytc1）之間的 電子傳遞,從而影響整個電子傳遞鏈的功能。

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  生理結果：

- 電子傳遞鏈被阻斷

=>質子不能被泵出線粒體內膜

=> 質子動力勢(proton motive force)降低

=>ATP合成減少

=>活性氧(ROS)產生增加

 

(A) Inhibition of complex I, leading to decreased electron transport and reduced ATP production.
錯誤：antimycin不作用於Complex I
而是作用在Complex III,
(B) Inhibition of complex II causing disruption in the citric acid cycle and impaired generation of reducing equivalents.錯不是直接作用於Complex II，而是作用在Complex III,
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(C) Inhibition of complexIII, resulting in the blockade of electron transfer and a decrease in the proton motive force.
對作用在(Complex III)
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(D) Inhibition of ATP synthase, preventing the conversion of the proton motive force into ATP synthesis.
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Antimycin 不會直接攻擊 ATP 合酶，它作用在電子傳遞鏈的 Complex III。
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為什麼Antimycin不會直接抑制ATP synthase：
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Antimycin只會間接影響ATP synyhase，不會直接影響
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當電子傳遞鏈受阻時，質子無法持續泵入膜間隙，導致質子梯度減弱或消失。沒有足夠的質子梯度，ATP合酶就無法有效地利用質子梯度合成ATP，ATP的產量就會大幅下降。
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(E) Inhibition of complex TV, leading to the disruption of the final step in the electron transport chain and a decrease in oxygen consumption.不是作用於Complex IV
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