48.下列有關buspirone之敘述，何者正確？
(A)作用機轉為partial 5-HT2A agonist
(B)具鎮痛效果
(C)具有azaspirodecanedione之結構
(D)主要代謝物為1-pyrazinylpiperazine

答案：登入後查看
統計： A(684), B(100), C(2023), D(712), E(0) #442608

詳解 (共 10 筆)

#1422653
樓上的D應該是1-(2-pyrimidinyl)piperazine (1-PP)
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#2576572

48.下列有關buspirone之敘述，何者正確？ 

(A)作用機轉為partial 5-HT2A agonist (partial 5-HT1A agonist)

(B)具鎮痛效果 (鎮靜抗焦慮)

(C)具有azaspirodecanedione之結構 

(D)主要代謝物為1-pyrazinylpiperazine  (1-(2-pyrimidinyl)-piperazine (1-PP) 能阻斷Alpha2-adranoceptor)


2019/06/26 更正

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#2586289

buspirone 

azaspirodecanedione

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#860573
 (A)作用機轉為partial 5-HT1A agonist 
(B)不具鎮痛效果 
(D)主要代謝物為1-(2-pyrazinyl)-piperazine (1-PP) 能阻斷Alpha2-adranoceptor
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#860571

662d5bf0.png#s-676,270Azaspirodecanedione5fd97d98.png#s-180,200

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#2763076

主要代謝物不是1-(2-pyrimidyl)-piperazine （1-PP)嗎?

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#1542619

具鎮靜抗焦慮效果

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#6095894
【buspirone 歷屆國考考點統整表...

(共 1765 字，隱藏中）
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#5177410

Buspirone

5177410-6261ea3aed0e3.jpgAzaspirodecanedione結構 

> 5-HT1A partial agonist，也作用於D2、5-HT2A

> 治療焦慮症（純抗焦慮，輕微鎮靜；無抗痙攣和肌肉鬆弛作用）；不太會產生依賴性

> 唯一缺點為onset太慢（1~2週）；須注意肝功能


***辨別：Bupropion：NDRI；抑制Dopamine&NE；治療憂鬱症（Welllbutrin®）&戒煙（Zyban®）【→體重下降、高劑量引起癲癇】

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#810377
In vitro preclinical studies have shown that Buspirone has a high affinity for serotonin (5-HT1A) receptors. Buspirone has no significant affinity for benzodiazepine receptors and does not affect GABA binding in vitro or in vivowhen tested in preclinical models.
 
Buspirone hydrochloride is an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs.
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私人筆記 (共 1 筆)

私人筆記#913760
未解鎖
buspirone具有azaspirod...

(共 44 字，隱藏中）
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