53.下列何種抗癲癇藥之主要作用標的為GABAA受體?
(A)
(B)
(C)
(D)
答案:登入後查看
統計: A(419), B(615), C(387), D(1747), E(0) #3283093
統計: A(419), B(615), C(387), D(1747), E(0) #3283093
詳解 (共 8 筆)
#6268289
前面有人寫錯 後面就跟著錯ㄌ
ㅤㅤ
C是Lamotrigine
補充考點:
1.機轉:抑制電位依賴性Na、Ca離子通道,抑制Glutamate釋放
2.治療大、小、局部發作
3.孕婦可用
4.SE:複視、紅疹、嗜睡
5.結構含Triazine
6.代謝:N2-glucuronidation
7.跟Valproic acid併用時,Lamotrigine的半衰期會被延長
(ethosuximide也是)
代謝圖:

15
0
#6217653
(A)是phenytoin,作用在Na離子通道
(B)是valporic acid
(C)是Lamotrigine
(D)是phenobarbital
6
1
#6206843
Phenobarbital increases the duration of time chloride channels are open, depressing the central nervous system. This action occurs by acting on GABA-A receptor subunits.
1
1