54 用於治療糖尿病之藥物中，下列何者不會促進胰島素分泌？
(A) chlorpropamide
(B) glyburide
(C) repaglinide
(D) metformin

答案：登入後查看
統計： A(41), B(12), C(37), D(282), E(0) #438792

詳解 (共 3 筆)

#5809174
Metformin 機轉： 增加周邊組織...
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#850722
Drug Classes → Metabolic Agents → Antidiabetic Agents → Meglitinides: repaglinide 
Meglinitides work by stimulating the pancreas to release insulin in response to a meal. It closes ATP-dependent potassium channels in functioning pancreatic beta cells. This blockade of potassium channels depolarizes the beta cells, which leads to opening of calcium channels resulting in influx of calcium. Increased intracellular calcium induces insulin secretion.

Meglitinides are used in the treatment of Type 2 diabetes.
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#850723
Metformin is an oral antidiabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, in particular, in overweight and obese people and those with normal kidney function.
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