58 下列關於Enalapril 之敘述，何者錯誤？
(A)屬於一種pro-drug
(B)為一種長效型ACE 抑制劑
(C)結構中具有二個chiral centers
(D)結構中具有一個free carboxylic acid

答案：登入後查看
統計： A(89), B(188), C(410), D(205), E(0) #416492

詳解 (共 5 筆)

#977184
(C)結構中具有三個chiral cen...
(共 26 字，隱藏中）
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#1019173
%252522Enalapril.svg.png%252522.png
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#3139571

複習:

和ACE的Zn鍵結基團可分為

1.sulfhydryl:最易和Zn鍵結，易引起皮疹、味覺異常。ex.Captopril

2.carboxylic acid: ex.Lisinopril、Enalapril

3.phosphinic acid: ex. Fosinopril

Enalapril、Fosinopril被酯化成prodrug，使B.A提高。

59 ACE 抑制劑於身體中主要會與下列何種金屬離子結合而產生藥效？ 
(A)Cu 2+ 
(B)Fe 2+ 
(C)Mg 2+ 
(D)Zn 2+ 

專技 - 藥理學與藥物化學- 100 年 - 100-1-藥師-藥理學與藥物化學#10028 

61 Fosinopril能與ACE中Zn 2+ 結合之活性官能基為： 

 
(A)  98-2-%2525E8%252597%2525A5%2525E7%252590%252586%2525E5%2525AD%2525B8%2525E8%252588%252587%2525E8%252597%2525A5%2525E7%252589%2525A9%2525E5%25258C%252596%2525E5%2525AD%2525B8-61-1.png
 
(B)  98-2-%2525E8%252597%2525A5%2525E7%252590%252586%2525E5%2525AD%2525B8%2525E8%252588%252587%2525E8%252597%2525A5%2525E7%252589%2525A9%2525E5%25258C%252596%2525E5%2525AD%2525B8-61-2.png
 
(C)  98-2-%2525E8%252597%2525A5%2525E7%252590%252586%2525E5%2525AD%2525B8%2525E8%252588%252587%2525E8%252597%2525A5%2525E7%252589%2525A9%2525E5%25258C%252596%2525E5%2525AD%2525B8-61-3.png
 
(D) 98-2-%2525E8%252597%2525A5%2525E7%252590%252586%2525E5%2525AD%2525B8%2525E8%252588%252587%2525E8%252597%2525A5%2525E7%252589%2525A9%2525E5%25258C%252596%2525E5%2525AD%2525B8-61-4.png

專技 - 藥理學與藥物化學- 98 年 - 098-2-藥師-藥理學與藥物化學 #10010

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#4725123
一. 不靠腎排.是肝排T.F.M (聽F...
(共 164 字，隱藏中）
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#6124724
除了Captopril、Fosinopril和Benazepril是兩個不對稱碳，其他ACEI都含有三個不對稱碳
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