6. Which of the following statements is correct regarding the replication folk? (A) Topoisomerase acts to separate two strands of duplex DNA. (B) Synthesis of the two strands of DNA is not simultaneous. (C) The lagging strand is the strand on which the polymerase moves in the same direction as the movement of the replication fork. (D) The DNA fragment formed on the lagging strand is called the Okazaki fragment. (E) Primase acts to join breaks in the phosphodiester backbone of DNA.