61. Nitric oxide (NO) is synthesized from:
(A) lysine
(B) citrulline
(C) spermine
(D) spermidine
(E) aiginine

62. In the binding of oxygen to hemoglobin, the relationship between the concentration of oxygen and the fraction of binding sites occupied can be best described as: (A) hyperbolic (B) linear with a negative slope (C) linear with a positive slope (D) random (E) sigmoidal

63. Which one is the essential ingredient for biosynthesis of fatty acid?  (A) (B)(C) (D) (E)

64. The urea cycle and citric acid cycle are linked by (A) citrulline and fumarate. (B) citrulline and ornithine. (C) citrulline and argininosuccinate. (D) ornithine and arginine. (E) fumarate and aspartate.

65. Which one is not a derivative of cholesterol? (A) cortisol (B) testosterone (C) arachidonic acid (D) bile acid (E) vitamin D3

66.5-Fluorouracil (5-FU) is used to treat cancers. It is a mechanism-based inhibitor of______. (A) ribonucleotide reductase (B) Ihymidylate synthase (C) adenylosuccinate lyase (D) GMP synthetase (E) xanthine oxidase

67. In amino acid metabolism, threonine is converted into acetyi-CoA and pyruvate while proline is converted into a-ketoglutarate. Classify each of these amino acids. (A) Threonine and proline are ketogenic. (B) Threonine is ketogenic and glucogenic； proline is ketogenic. (C) Threonine is ketogenic； proline is glucogenic. (D) Threonine is ketogenic and glucogenic； proline is glucogenic. (E) None of the above.

68. Ketone bodies are produced by file β-oxidation of an excess of acetyl-CoA. Which of the followings are ketone bodies? (A) ①②③ (B) ①③④ (C) ②④ (D) ③④ (E) ②④⑤

69. Many biomolecules are derived from amino acid precursors. Serotonin and dopamine are synthesized from ____and____ , respectively. (A) histidine； tyrosine (B) phenylalanine； tryptophan (C) tryptophan； tyrosine (D) histidine； tryptophan (E) tryptophan； histidine

70. Several nucleotide bases undergo spontaneous loss of their exocyclic amino groups (deamination). Deamination of the nucleotide bases cytosine and 5‑methylcytosine yields nucleotide bases:(A) hypoxanthine and xanthine, respectively.(B) uracil and thymine, respectively.(C) uracil only.(D) uracil and hypoxanthine, respectively.(E) thymine and uracil, respectively.

71. If a cell were unable to synthesize or obtain tetrahydrofblic acid (H4 folate), it would probably be deficient in the biosynthesis of: (A) isoleucine (B) leucine (C) lysine (D) methionine (E) serine

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