62. Which description about Hb (hemoglobin) is false?
(A) HbF has an α2γ2 structure.
(B) HbA has an α2β2 structure.
(C) HbF has a much higher affinity for 2,3-BPG than HbA does.
(D) 2,3-BPG lowers the O2 affinity of HbA.
(E) 2,3-BPG is found inside red blood cells.

58. Which of the following descriptions regarding neuronal disorders is correct? (A) Amyloid plaques are always observed in schizophrenia. (B) Additive substances such as alcohol affect the dopamine regulation in brain. (C) Dopamine can be used to treat Alzheimer patients. (D) Parkinson's patients lost their ability to recognize people. (E) Depression is a rare nervous system disorder.

59. Which of the following descriptions regarding muscle is correct? (A) The length of thick filament will change in fully muscle contraction. (B) A motor unit consists of multiple motor neurons and muscle fibers. (C) Myoglobin binds oxygen tighter than hemoglobin does. (D) Ca2+ binds with tropomyosin to initiate muscle contraction. (E) Insect's skeletal muscles are grossly different from those of vertebrates.

60. Radiolabelled isotope dating is an important method to determine the age of a fossil. A 14C content analysis of an animal fossil showed that its content is 0.01562 fold as much 14C as the atmosphere. The half-life of 14C is 5730 years. The age of the fossil is close to which of the following? (A) 1000 years (B) 5730 years (C) 35000 years (D) 70000 years (E) 100000 years

61. Which of the following descriptions about the Michaelis-Menten equation is false? (A) KM measures the substrate concentration at which the reaction rate is 1/2Vmax. (B) An enzyme with a low KM means that it has low affinity for its substrate. (C) An enzyme with a low kcat means that it has a low catalytic rate. (D) The turnover number, kcat, measures the rate of the catalytic process. (E) The ratio kcat/KM is a convenient measure of enzyme efficiency.

63. The carbon skeleton produced by transamination of aspartate enters the citric acid cycle as ______. (A) acetyl-CoA (B) pyruvate (C) fumurate (D) oxaloacetate (E) α-ketoglutarate

64. 5-phosphoribosyl-1-pyrophosphate (PRPP) is a precursor in the synthesis of all of the following products except ________. (A) histidine (B) tryptophan (C) arginine (D) UMP (E) AMP

65. In eukaryotic cells, mRNA modification includes __________. (A) splicing out exons and join introns (B) add a cap at 3’ end to protect the 3’ end (C) add a phosphate group at 5’ end to increase stability (D) remove nucleotides at 3’ end before addition of a poly A tail (E) remove 3’UU and attach CCA

66. What is the appropriate order for oxidation of glucose to CO2, H2O and ATP? 1.convert pyruvate to acetyl CoA 2.electron-transport chain 3.citric acid cycle 4.oxidative-phosphorylation 5.glycolysis (A) 3→5→1→4→2 (B) 5→1→3→2→4 (C) 1→4→5→2→3 (D) 3→1→4→2→5 (E) 4→1→3→5→2

67. Cooperative binding of a ligand to a protein is a form of allosteric binding. Which of the following statements is false? (A) It is usually associated with proteins with multiple subunits. (B) The binding of one ligand affects the affinities of other unfilled binding sites. (C) The Hill plot results in a hyperbolic curve. (D) It results in a sigmoidal binding curve. (E) Hill coefficient (nH) is a measure of the degree of cooperativity.

68. Ubiquitin is a small protein which is covalently linked to proteins designated for destruction via ____. (A) ATP-dependent proteases in lysosomes (B) ATP-dependent proteases in proteasomes (C) ATP-dependent proteases in ribosomes (D) ATP-independent proteases in endosomes (E) ATP-independent proteases in peroxisomes