69.口服避孕藥與抗生素併用時,透過何種機制產生藥品交互作用?
(A)改變腸道的菌叢
(B)改變尿液的酸鹼值
(C)改變腸胃道的酸鹼值
(D)改變腸胃道的蠕動速度
答案:登入後查看
統計: A(5044), B(71), C(259), D(58), E(0) #1541409
統計: A(5044), B(71), C(259), D(58), E(0) #1541409
詳解 (共 8 筆)
#2242301
(A)77 Ampicillin 與含 ethinyl estradiol(EE)的口服避孕藥併用,則 EE 所受影響主要為何?
(A) 腸肝循環(enterohepatic circulation)受抑制
(B) 在肝臟的代謝被促進
(C) 在肝臟的代謝被抑制
(D) 與白蛋白的結合被取代
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#2350221
抗生素改變腸道的菌叢 且使避孕藥腸肝循環受抑制 !!
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#2925531
避孕藥被腸道菌叢水解後才能被再吸收並進入腸肝循環
A proposed (yet otherwise unproven) mechanism for this potential interaction is based on the antibiotic's ability to reduce gut bacteria which are important for hydrolysis of conjugated estrogen, which subsequently permits the reabsorption of the estrogen (ie, enterohepatic circulation is interrupted, resulting in lower serum concentrations of the estrogen).
UpToDate Lexicomp Estrogen Derivatives (Contraceptive) / Penicillins
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#2347622
避孕藥中含有的雌性激素會因為腸道中益生菌的作用而維持在穩定的濃度,Tetracyclines、Amoxicillin等抗生素容易影響其效果
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