69. 關於 Liver Imaging Reporting and Data System (LI-RADS) system，下列敘述何者錯誤？
(1) A LI-RADS 2 lesion has an average probability of HCC of 33%.
(2) A LI-RADS 4 lesion has an average probability of HCC of 80%.
(3) For LI-RADS M lesions, 42% had HCC and 57% had another tumor besides HCC.
(4) 6%-15% of LI-RADS 3 lesions followed prospectively were diagnosed as HCC or other malignancy by 24 months.
(5) Threshold growth (= size increase of a mass by ≥ 50% in ≤ 6 months) is a criterion for LI-RADS 4.
(A) (1)＋(5)
(B) (1)
(C) (1)＋(4)
(D) (1)＋(3)＋(5)

(E) (1)＋(3)

65. 下列關於核(苷)酸類似物(nucleoside or nucleotide analogs)在慢性 B 型肝炎之治療，何者描述正確？(1) 針對 HBeAg 陽性患者須長期使用，直到 e 抗原血清陰轉，再施予鞏固療法一年，可以降低停藥後復發(relapse)的機率。(2) 針對 HBeAg 陰性患者須終身使用口服藥，因為停藥後病毒學復發與臨床復發的機率非常高。(3) 針對肝硬化患者須避免終身使用口服藥，因為會降低功能性痊癒的機會。(4) 準備停藥當下可以檢測血清 HBsAg 濃度，一般而言 HBsAg 濃度越低(例如小於 100 ng/mL)停藥後復發機率愈低。(5) 停藥後一旦發生病毒學復發，應馬上給予抗病毒藥物治療避免肝失代償風險。(A) (1)＋(2)＋(3)＋(4)＋(5)(B) (1)＋(2)＋(3)＋(4)(C) (1)＋(3)＋(4)(D) (1)＋(4)＋(5)(E) (1)＋(4)

66. 關於中期肝癌 TACE unsuitable 的範圍，2020 APPLE Expert Consensus Statement 與 BCLC 2022 update 比較，其中包括下列何種共同項目？(1) Up-to-7 out(2) Infiltrative type(3) Bilobar extensive HCC(4) Extranodular growth type HCC(5) Poorly differentiated HCC(A) (2)＋(3)(B) (1)＋(2)＋(3)(C) (2)＋(3)＋(4)＋(5)(D) (2)＋(3)＋(5)(E) (1)＋(2)＋(3)＋(4)＋(5)

67. 依據 2018 AASLD Guidelines for the Treatment of Hepatocellular Carcinoma，下列何者敘述正確？(1) The AASLD suggests that patients beyond the Milan criteria (T3) should beconsidered for liver trans-plantation after successful downstaging into the Milan criteria.(2) The AASLD recommends LRT over no treatment in adults with cirrhosis andHCC (T2 or T3, no vascular involvement) who are not candidates for resection or transplantation.(3) The AASLD suggests routine use of adjuvant therapy for patients with HCC following successful resection or ablation.(4) The AASLD suggests not performing surveillance of patients with Child-Pugh class C cirrhosis unless they are on the transplant waiting list.(A) (3)＋(4)(B) (1)＋(2)(C) (3)(D) (1)＋(2)＋(4)(E) (1)＋(2)＋(3)＋(4)

68. 關於 Liver Imaging Reporting and Data System (LI-RADS) system，下列敘述何者錯誤？(1) LI-RADS 1 and LI-RADS2 indicate definitely and probably benign.(2) LI-RADS 5 indicates definite HCC.(3) “a small nodular area of CT/MR arterial phase hyperenhancement, which isnot present on other phases” is classified as LI-RADS 2.(4) “a ≥2-cm encapsulated lesion with CT/MR arterial phasehyperenhancement, but without “washout” is classified as LI-RADS 4.(5) “a ≥2-cm lesion that enhances to the same degree as liver in the CT/MRarterial phase, but enhances less (i.e., is hypoenhanced) in the postarterial phases” is classified as LI-RADS 4.(A) (1)＋(4)(B) (2)＋(3)(C) (3)(D) (2)＋(3)＋(5)(E) (3)＋(5)

70. 依據 2018 AASLD practice guidance，關於 HCC 診斷，下列敘述何者正確？(1) Diagnosis of HCC can be made by imaging in patients without cirrhosis, ifenhancement and washout are present.(2) Histological markers GPC3, HSP70, and GS can be assessed to distinguishhigh-grade dysplasia from HCC on histology if HCC cannot be diagnosed based on routine histology.(3) A lesion of ＞1 cm on ultrasound (US) should trigger recall procedures for the diagnosis of HCC.(4) If using AFP with US, then an AFP ＞20 ng/mL should trigger recall procedures for diagnosis of HCC.(A) (1)(B) (2)＋(3)(C) (1)＋(4)(D) (2)＋(3)＋(4)(E) (1)＋(2)＋(3)＋(4)

71. GALAD model 可以運用在 HCC 診斷，下列何者不屬於 GALAD model 的組成項目？(A) Gender(B) AFP and AFP-L3%(C) DCP (protein induced by vitamin K absence/antagonist-II)(D) Age(E) Alcohol

72. 依據 BCLC 2022 update，下列何者錯誤？(1) For solitary HCC, the presence of CSPH (defined by a hepatic venous pressure gradient [HVPG] ＞10 mmHg) is the key consideration to decide treatment option.(2) For BCLC A, multifocal disease still within the Milan criteria is better served by liver transplantation (LT).(3) For BCLC 0, LT is not considered.(4) BCLC A is defined as solitary HCC irrespective of size or as a multifocal HCC up to 3 nodules (none of them ＞3 cm), without macrovascular invasion, extrahepatic spread or cancer-related symptoms.(A) (3)(B) (2)(C) (2)＋(3)(D) (3)＋(4)(E) (2)＋(5)

73. 依據 BCLC 2022 update，BCLC B 下列何者錯誤？(1) The treatment options include LT, TACE and systemic therapy.(2) AFP higher than 1,000 ng/dl is currently applied as an exclusion criterion ofLT in BCLC B HCC.(3) BCLC B patients with an AFP ＞1,000 ng/ml who experienced biochemicalresponse (at least a decrease to less than 500 ng/ml) to locoregional therapies have post-LT outcomes inferior to those reported for patients within Milan criteria.(4) For patients to be candidates for TACE, increased bilirubin beyond 2 mg orslight fluid retention requiring diuretic treatment are suboptimal survival afterTACE.(A) (3)(B) (2)(C) (2)＋(3)(D) (3)＋(4)(E) (1)＋(3)

74. 依據 2018 HCC EASL Clinical Practice Guidelines，TACE 的敘述下列何者正確？(1) Drug-eluting beads has shown similar benefit to conventional TACE.(2) Segmental or sub-segmental portal vein tumor invasions are absolute contraindications for TACE.(3) There is insufficient evidence to recommend scores that better select BCLC-B candidates for first TACE or for subsequent sessions.(4) Patients with biliary-enteric anastomosis or biliary stent are at higher risk ofhepatic abscess by TACE.(A) (1)＋(3)＋(4)(B) (1)＋(2)＋(3)(C) (2)＋(3)＋(4)(D) (1)＋(2)＋(3)＋(4)(E) (1)＋(4)

75. 關於 HCC systemic therapy 的敘述下列何者正確？(1) Systemic chemotherapy with doxorubicin or FOLFOX did not demonstrate survival benefits.(2) Lenvatinib targets VEGFR1-3; fibroblast growth factor receptor (FGFR1-4);platelet-derived growth factor receptor α, RET, and KIT.(3) Cabozantinib is a MET, VEGFR2 and RET inhibitor approved for thyroid,renal cancer and HCC.(4) Ramucirumab is a monoclonal antibody targeting VEGFR 1-3.(5) Atezolizumab plus cabozantinib showed a superiority to sorafenib in median progression-free survival (PFS).(A) (1)＋(2)(B) (1)＋(2)＋(3)(C) (2)＋(3)＋(4)(D) (1)＋(2)＋(3)＋(5)(E) (1)＋(2)＋(3)＋(4)＋(5)