7. ______enzyme relaxes the supercolling of double stranded DNA molecule (A) DNA Polymerase (B) DNA helicase (C) DNA Ligase (D) Topoisoemerase

(5) Which of the followings is most likely to lead to a loss of gene function? (A) A missense mutation in the open reading frame (B) A frameshift mutation in the coding region (C) A change from a T to C in the promoter region (D) A change from a TAA codon to a TAG codon in the coding region (E) A sequence change in the 3' untranslated region