70. Sickle-cell anemia is caused by__________. (A) a decreased production of α chains of hemoglobin. (B) a substitution of a Glu residue for a Phe residue at the β6 position. (C) the loss of the heme group because the proximal His is oxidized. (D) a substitution of a Val residue for a Glu residue at the β6 position. (E) a substitution of Glu residue for His at the C-terminal of the α chain.

13. Suppose a person begins breathing very rapidly while resting (hyperventilating), which of the following best describes how homeostasis is restored? (A) Rapid breathing decreases blood CO2 levels, thereby raising blood pH. The frontal cortex detects the change and reduces stimulation of the rib muscles and the diaphragm, thereby decreasing the breathing rate. (B) Rapid breathing increases blood CO2 levels, thereby causing the blood pH to drop. The hypothalamus detects the change and decreases stimulation of the rib muscles and the diaphragm, thereby reducing the breathing rate. (C) Rapid breathing decreases blood CO2 levels, thereby raising blood pH. The hypothalamus detects the change and reduces stimulation of the rib muscles and the diaphragm, thereby decreasing the breathing rate. (D) Rapid breathing increases blood CO2 levels, thereby causing the blood pH to drop. The medulla oblongata detects the change and reduces stimulation of the rib muscles and the diaphragm, thereby decreasing the breathing rate. (E) Rapid breathing decreases blood CO2 levels, thereby raising blood pH. The medulla oblongata detects the change and reduces stimulation of the rib muscles and the diaphragm, thereby decreasing the breathing rate.

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