試題詳解

82. What is the main pharmacological action of benzoate and phenylbutyrate, which are used to treat urea cycle disorders?
(A) It provides intermediates required for the urea cycle to enhance the efficiency of the entire urea cycle.
(B) It acts as allosteric activators of carbamoyl phosphate synthase I to enhance the efficiency of the urea cycle.
(C) Their metabolites combine with glycine and glutamine, respectively, to form derivatives that are excreted, reducing the burden on the urea cycle.
(D) It promotes the synthesis of arginine to prevent arginine deficiency.
(E) It increases the activity of ornithine transcarbamylase to facilitate urea synthesis.