試題詳解

89. Which step about regulation of gene expression by insulin is not correct?
(A) Insulin receptor binds insulin and undergoes autophosphorylation.
(B) Insulin receptor binds IRS-1 on its Tyr residues. SH3 domain of Grb2 binds to phosphorylated Tyr of IRS-1.
(C) Sos binds to Grb2, then to Ras, causing GDP release and GTP binding to Ras.
(D) Activated Ras binds and activates Raf-1.
(E) Raf-1 phosphorylates MEK. MEK phosphorylates MAPK, activating it.