90. Which of the following statements is correct regarding reversible inhibition of enzymes? ① The catalytic efficiency of enzyme is in the presence of competitive inhibitors. ② Competitive inhibitors are substrate analogs or transtion state analogs. ③ Uncompetitive inhibitors combine only with enzyme-substrate complex. ④ In the presence of inhibitors, the initial rate of enzyme-catalyzed reactions is positively correlated with substrate concentration. ⑤ The binding of noncompetitive inhibitors to enzymes is inhibited by substrate. (A) ①②③ (B) ②③④ (C) ③④⑤ (D) ①③④ (E) ②④⑤