It is indisputable that music can make people happy, neurochemical material which makes human happy can also echance immune system. However, it’s very complex about neurophysiological machanism related to hunan and pleasure. Human brain has certainly its own “pleasure center”, but still many different other neurotransmitters and areas of brain would lead to pleasure. In the aspect of research, though many cases indicate music has positive effect on patients, sometimes even profoundly amazing, there is little documents which truly conduct experiments and record it. Many anecdotes impressed, but could not constitute scientific research proof.