二、申論題(共 70 分)1. 近年來，各界對於大數據和開放資料等議題日益關注。政府機關擁有龐大的民眾檔案，例如教育成績、社福身分、健康醫療等等。現有社福單位希望串連多個公部門大型資料庫進行次級分析，以辨識和偵測具有高暴力犯罪風險的青少年。試從研究倫理的角度，舉出兩個潛在疑慮進行說明，(10 分)並針對上述疑慮，提出相應的預防策略。(10 分)

II.Short Questions (40%) 1. A nonapeptide was determined to have the following amino acidcomposition: (Lys)2, (Gly)2, (Phe)2, His, Leu, Met. The native peptidewas incubated with 1-fluoro-2, 4-dinitrobenzene (FDNB) and thenhydrolyzed 2,4-dinitrophenylhistidine was identified by HPLC. Whenthe native peptide was exposed to cyanogen bromide (CNBr), anoctapeptide and free glycine were recovered. Incubation of thenative peptide with trypsin gave a pentapeptide, a tripeptide, andfree Lys. 2,4-Dinitrophenyl- histidine was recovered from thepentapeptide, and 2,4-dinitrophenylphenylalanine was recoveredfrom the tripeptide. Digestion with the enzyme pepsin produced adipeptide, a tripeptide, and a tetrapeptide. The tetrapeptide wascomposed of (Lys)2, Phe, and Gly. What is the native sequence?(10%)

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