申論題

9. The AUC and AUMC values of drug-A following an I. V. bolus of 5 mg are 278 ug-hr²/L, and 1 390 pg-hr?/L, respectively. The plasma concentration profile of this drug can be described by one-compartment model. Calculate the volume of distribution at steady-state (Vdss) of this drug (10 points)