4. Eukaryotic RNA polymerase II required transcription factors for transcription. Which transcription factor can recognize a common promoter (TATA box)? Which transcription factor is responsible for phosphorylation on C-terminal domain of RNA polymerase II and what is the physiological meaning for such phosphorylation? (8%)

3. Why does liver damage cause jaundice? (5%)

2. High levels of cholesterol in the blood is positively correlated with the incidence of atherosclerosis. The ratio of LDL: HDL is a better indicator of coronary artery obstruction, Why? (6%)

40. Which of following statements are TRUE:
(A) Hydrophobic means it is water-like
(B) Nucleic acid dissolved in water is because it is a negatively charged molecule.
(C) Sodium acetate solution can not neutralize the charge of nucleic acid
(D) The principle of ethanol precipitation is based on nucleic acid is not able to dissolved
in ethanol
(E) Glycogen can be precipitated with nucleic acid during ethanol precipitation

39. Which of the following statements for RNA interference are TRUE:
(A) RNA interference is a prototype of immune system in lower eukaryotes
(B) Argonaute protein is the enzyme cleaves target RNA
(C) microRNA and RNA interference adopt very similar mechanism in generating the small RNA
(D) Long double strand RNA can initiate RNA interference in any organism
(E) One of the nature function of RNA interference in mammals are virus clearance

38.For the statements of various biological processes in different cell compartments, which statements are TRUE
(A) Nucleolus is located in the nucleus
(B) rRNA are accumulated in the nucleolus
(C) RNA synthesis takes place in the cytoplasm
(D) DNA replication takes place in nucleolus
(E) Mitochondria has its own DNA