複選題
10. Which of the following is most likely to lead to a loss-of-function of a gene?
(A) A change from T to C in the promoter region
(B) A missense mutation in the open reading frame
(C) A frameshift mutation in the coding region
(D) A sequence change in the 3’ untranslated region
(E) A change from a TAA codon to a TAG codon in the coding region