試題詳解

9. Please choose one     correct     answer from the following statements related to general transcription factors in eukaryotes.
(A) In eukaryotic transcription, TATA-box-binding protein (TBP) binds to the major groove of the TATA box and forces DNA to bend.
(B) From structural studies on a TFIIB-RNA polymerase II complex, TFIIB binds to TBP at the TATA box via its C-terminal domain and to RNA polymerase II via its N-terminal domain.
(C) Both TFIIE and TFIIH are required for transcription initiation and elongation, but not for promoter clearance.
(D) TFIIS has a DNA helicase activity that is important for eukaryotic transcription initiation.
(E) TBP is only required for transcription of genes regulated by RNA polymerase II.