10. Which of the following statement is not true ? (A) DRB sensitivity inducing factor (DSIF) and negative elongation factor (NELF) can help eukaryotic RNA polymerase II in the paused state. (B) TFIIH can catalyze phosphorylation of the carboxyl-terminal domain of RNA polymerase II and is required for promoter clearance, but is not needed for transcription elongation. (C) The signal for RNA polymerase II to leave the paused state is delivered by the positive elongation factor-b (P-TEFb). (D) P-TEFb phosphorylates RNA polymerase II, DSIF and NELF. Next, DSIF leaves the paused complex, but NELF remains to stimulate transcription elongation. (E) TFIIB binds to TATA-binding protein via its C-terminal domain (TFIIBC) and can determine the start site of transcription.