14.下列藥物中，何者為治療Paget disease的第一線用藥？
(A)tiludronate
(B)cinacalcet
(C)raloxifene
(D)ibuprofen

from uptodate-Treatment of Paget disease of bone (https://www.uptodate.com/contents/treatment-of-paget-disease-of-bone?search=Paget%20disease&source=search_result&selectedTitle=2~123&usage_type=default&display_rank=2#)

Paget disease of bone (PDB), also known historically as osteitis deformans, is a focal disorder of bone metabolism that occurs in the aging skeleton; it is characterized by an accelerated rate of bone remodeling, resulting in overgrowth of bone at single (monostotic PDB) or multiple (polyostotic PDB) sites and impaired integrity of affected bone. Commonly affected areas include the skull, spine, pelvis, and long bones of the lower extremity.

The nitrogen-containing bisphosphonates (eg, zoledronic acid, risedronate, and alendronate) are effective, relatively safe, and have advantages for the treatment of Paget disease compared with the simple bisphosphonates (eg, etidronate, tiludronate) or calcitonin. The nitrogen-containing bisphosphonates have different mechanisms of action than the simple bisphosphonates, resulting in sustained suppression of bone turnover at doses that do not impair mineralization

雖然根據uptodate上的資訊Tiludronate不是第一線用藥，但選一個最接近的(?