28. Which of the following statements about Trypanosomes and their interaction with hosts and the immune system is correct? (A) Trypanosomes have a simple life cycle that involves only one host and does not require a vector for transmission. (B) The primary mechanism of immune evasion in Trypanosomes is the constant change of their surface glycoproteins (VSGs) through gene rearrangement, allowing them to avoid detection by the host's immune system. (C) The gene rearrangement in Trypanosomes is triggered by the host's immune response, leading to a temporary suspension of VSG production and a dormant state in the parasite. (D) Coevolution with humans has led to Trypanosomes becoming less virulent, resulting in a symbiotic relationship where the parasite does not harm the host. (E) The immune system of secondary hosts, such as tsetse flies, plays a crucial role in the suppression and elimination of Trypanosomes, preventing their transmission to humans.