阿摩線上測驗
3 下列有關 Tamoxifen 的敘述，何者錯誤？
(A)用於治療對原發部位腫瘤有 estrogen receptor 的停經後乳癌婦女
(B)會減低血清中 insulin-like growth factor 的濃度
(C)會減低腫瘤內基質細胞（stromal cell）的轉化生長因子 β（TGF-β）的濃度
(D)它是一種有口服製劑之非類固醇藥物
答案：登入後查看
統計： A(69), B(424), C(691), D(272), E(0) #415910
統計： A(69), B(424), C(691), D(272), E(0) #415910
詳解 (共 7 筆)
Swear
#1213911
TGF-β（ transforminggrowth factor-β）是一種多效細胞因子，在許多癌細胞中有效的抗有絲分裂和促凋亡效應。實驗證實Tamoxifen可誘發腫瘤細胞內的TGF-β濃度上昇而達到治療乳癌的目的。
112
0
Bryan
#891311
10 下列有關 tamoxifen 之敘述，何者錯誤？
(A)對於停經後的女性比停經前的女性藥效佳
(B)通常會引起噁心、嘔吐的作用
(C)臨床上用於治療乳癌
(D)其作用與 estrogen receptor 的多少無關
專技高考◆藥師◆藥理學與藥物化學- 096-2-藥師-藥理學#10041
答案：D
29
1
Bryan
#891297
(C)會使腫瘤內基質細胞（stromal cell）的轉化生長因子 β（transforming growth factor beta,TGF-β）的濃度上昇。
15
2
Bryan
#855134
Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, 4-hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, and thus may be characterized as a mixed agonist/antagonist. Tamoxifen is the usual endocrine therapy for hormone receptor-positive breast cancer in pre-menopausal women, and is also a standard in post-menopausal women although aromatase inhibitors are also frequently used in that setting.
5
2
