3. Which of the following statements about histone modification is NOT correct? (A) Histone modifications change gene expression patterns without altering the actual nucleotide sequence of the DNA. (B) The addition of methyl groups to histone tails always leads to the immediate activation of the nearby gene by opening the chromatin structure. (C) Acetylation of histone tails generally neutralizes their positive charge, loosening the bond between histones and DNA to make the template more accessible for transcription. (D) Histone modifications occur primarily on the flexible N-terminal "tails" of the histone proteins that protrude outward from the core of the nucleosome. (E) Certain histone modifications can be inherited by daughter cells during mitosis, allowing a specific cell type to maintain its identity through successive cell divisions.