37. Which of the following statements about sickle cell anemia is incorrect?
(A) The red blood cells have a crescent shape making them difficult to pass
through the capillaries.
(B) Hb S (sickle hemoglobin) differs from normal Hb A by only one amino acid
substitution.
(C) The difference between the molecular structures of Hb S and normal Hb A is
the presence of a hydrophobic protrusion on the surface of Hb S protein.
(D) The solubility of dcoxyHb S is lower than that of deoxyHb A, so insoluble
Hb S fibers may be observed frequently.
(E) When binding with oxygen, Hb S can interact with the cell membrane and
cause cell damage.
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