42 下列那一種藥物可與核糖體之30S subunit 結合，抑制tRNA 攜帶的aminoacyl 部分進入acceptor site 與ribosome-mRNA 形成complex，抑制蛋白質的形成？
(A) Tetracycline
(B) Chloramphenicol
(C) Erythromycin
(D) Clindamycin

答案：登入後查看
統計： A(462), B(36), C(59), D(66), E(0) #496961

詳解 (共 6 筆)

#3319561

紅5四3

紅：erythromycin，50s

四：tetracycline，30s

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#4643748

資料來源：劉老師上課講義

Amphenicol : reversibly 50S binding, inhibit peptidyl transferase (transpeptidation)

新的tRNA進不來

Macrolide : 50S binding inhibit translocation

RNA無法自 A site 轉 P site

Tetracycline : 30S binding

新的tRNA進不來

606fb46a7af1e.jpg

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#5810324
tetracycline：bind re...
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3
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#3042745

作用在30S的只有AMG和四環

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#827399
Tetracyclines are broad-spectrum antibiotics derived from cultures of Streptomyces bacteria, and work by inhibiting protein synthesis after uptake into susceptible organisms. They work by reversibly binding to the 30S ribosome of the microbial RNA and preventing the attachment of aminoacyl-tRNA with the acceptor site on the 70S ribosome. Their activity is bacteriostatic and not bacteriocidal.
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#3968529
Clindamycin 作用在50S
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