64. Pompe disease is a glycogen storage disease caused by defect in ______.
(A) glycogen phosphorylase
(B) lysosomal α-1,4-glucosidase
(C) glycogen branching enzyme
(D) glucose-6-phosphatase
(E) phosphorylase kinase

60. ______ are NOT derived from myeloid stem cell. (A) Basophils (B) Erythrocytes (C) Lymphocytes (D) Monocytes (E) Platelets

61. Ribonucleotide reductase catalyzes the reduction of ribonucleotides to deoxyribonucleotides. Which of the following cofactors are essential for the activity of ribonucleotide reductase? ① NADPH； ② Thioredoxin； ③ NADH； ④ Glutaredoxin； ⑤ Tetrahydrofolate (A) ①,②,⑤ (B) ①,②,④ (C) ①,③,⑤ (D) ②,③,⑤ (E) ②,③,④

複選題62. In eukaryotic matured mRNA, which one of the following statements is FALSE? (AB) Both 5’ and 3’ ends contain a free 3-OH group on ribose. (AC) Intron is removed in the matured RNA. (AD) Poly( A ) tail is added to 3’ end in matured RNA. (AE) Methylation can be found on 5’ end. (BC) Splicing needs snRNAs. (BD)一律送分

63. A cell that is unable to synthesize or obtain tetrahydrofolate would probably be deficient in the biosynthesis of ______. (A) dGMP (B) dCMP (C) dAMP (D) dTMP (E) dUMP

65. Which of the following statements about allosteric regulation are CORRECT? ① Substrate is a heterotropic allosteric modulator. ② Allosteric regulation can increase or decrease the catalytic activity of enzymes. ③Allosteric enzymes typically have oligomeric structure. ④ The activity of some allosteric enzymes is regulated by feedback inhibition. ⑤ Allosteric modulators cannot induce conformational change of allosteric enzymes. (A) ①,②,③ (B) ①,②,④ (C) ①,③,④ (D) ①,③,⑤ (E) ②,③,④

66. Which of the following statements about ribozyme are CORRECT? ① Peptidyl transferase is a ribozyme. ②Aminoacyl-tRNA synthetase is a ribozyme. ③ The substrate of ribozyme is RNA. ④ Hammerhead ribozyme is involved in trans-splicing reaction. ⑤ RNase P is a ribozyme. (A) ①,②,③ (B) ①,③,④ (C) ①,④,⑤ (D) ①,③,⑤ (E) ②,④,⑤

67. Which of the following statements about microRNAs (miRNAs) are CORRECT? ① miRNAs originate from exogenous dsRNA. ② miRNAs form a perfect complementary to its target mRNA. ③ Some miRNAs can functionally inhibit mRNA translation. ④ Some miRNAs can promote mRNA decay. ⑤ miRNAs are transcribed by RNA polymerase III. (A) ①,⑤ (B) ②,③ (C) ③,④ (D) ②,④ (E) ③,⑤

複選題68. Which of the following statements about glycogen is FALSE? (A) Glucose-6-phosphate is released from nonreducing ends of the glucose polymer by the action of the enzyme glycogen phosphorylase. (B) In glycogen breakdown, it involves sequential phosphorolytic cleavages of α(1→4) bonds. (C) Glycogen is the storage polysaccharide in skeletal and liver cells. (D) Glycogen is a polymer of glucose in α(1→4) linkages with α(1→6) linked branches. (E) The breakdown of glycogen in skeletal muscle ultimately enters glycolysis to generate ATP.

69. Which of the following statements for Shine-Dalgarno sequence are CORRECT? ① Shine-Dalgarno sequence is found in prokaryotic mRNA. ② Shine-Dalgarno sequence is a purine-rich sequence. ③ Shine-Dalgarno sequence can base-pair with a sequence of tRNA. ④ Shine-Dalgarno sequence is involved in DNA replication. ⑤ Shine-Dalgarno sequence can base-pair with a sequence of 16S rRNA. (A) ①,②,③ (B) ①,②,⑤ (C) ①,③,④ (D) ①,④,⑤ (E) ①,②,④,⑤

70. Which of the following statements about nitric oxide (NO) are CORRECT? ① Cellular NO is produced from lysine. ② Nitroglycerine is an NO donor. ③ Nitric oxide synthase is involved in the production of NO. ④ Adenyl cyclases are receptors for NO. ⑤ NO production in endothelial cells leads to vasodilation. (A) ①,②,③ (B) ②,③,④ (C) ③,④,⑤ (D) ①,③,④ (E) ②,③,⑤