73 某藥在體內之藥物動力學遵循一室分室模式,其分布體積為20 L。當口服此藥400 mg 後之血中濃度(C p)變化可以公式C p (mg/L)=5(e -0.2t -e -1.0t ) 來描述,t 之單位為hr。請問此藥口服之生體可用率為多少%?
(A) 10
(B) 20
(C) 30
(D) 40
答案:登入後查看
統計: A(24), B(328), C(49), D(38), E(0) #415195
統計: A(24), B(328), C(49), D(38), E(0) #415195
詳解 (共 3 筆)
#821796
5 = FDKa/ [Vd (Ka-K)] = F x 400 x 1 / (20x0.8)
= F x 400 / 16
F = 0.2 = 20%
30
1
#2518523
AUC=DoseF/Cl = A/k - B/ka
=>>400*F/20*0.2 = 5/0.2 - 5/1.0
F=0.2=20%
26
0