阿摩線上測驗
79.下列penicillins中，何者與蛋白質結合率最高？
(A)oxacillin
(B)amoxicillin
(C)methicillin
(D)carbenicillin
統計： A(2478), B(1417), C(1027), D(1039), E(0) #2403465
詳解 (共 10 筆)
penicillin中，親脂性愈高，PB結合就愈高 → 這句話是Foye裡說的不是我亂說的
| (A)oxacillin | (B)amoxicillin | (C)methicillin | (D)carbenicillin |
耐酸又耐酶 |
較不耐酶 |
不耐酸耐酶 |
較不耐酸 |
[補充] 74 Oxacillin、cloxacillin、dicloxacillin 構造上除了青黴素的基本構造外，還有下列那一雜環？ (A) Imidazole (B) Pyrazole (C) Oxazole (D) Isoxazole 專技 - 藥理學與藥物化學- 100 年 - 100-1-藥師-藥理學與藥物化學#10028 ps. 題目這三位Oxacillin、cloxacillin、dicloxacillin 都是肝臟排泄，Naf是膽汁排泄，其他PN都是腎排泄 |
分享前人整理-清晰版本
統整表格整理
要記住最大和最小以及一些特別的
Penicillin | 來源 | 耐酸性 | 抗β-lactamase | 抗菌範圍 | 口服吸收 (%) | 蛋白質 結合率(%) |
Penicillin G | Biosynthetic | Poor | No | Intermediate | Poor(20) | 50-60 |
Penicillin V | Biosynthetic | Good | No | Intermediate | Good(60) | 55-80 |
Methicillin | Semisynthetic | Poor | Yes | Narrow | Nill | 30-40 |
Nafcillin | Semisynthetic | Fair | Yes | Narrow | Variable | 90 |
Oxacillin | Semisynthetic | Good | Yes | Narrow | Fair(30) | 85-94 |
Cloxacillin | Semisynthetic | Good | Yes | Narrow | Good(50) | 88-96 |
Dicloxacillin | Semisynthetic | Good | Yes | Narrow | Good(50) | 95-98 |
Ampicillin | Semisynthetic | Good | No | Broad | Fair(40) | 20-25 |
Amoxicillin | Semisynthetic | Good | No | Broad | Good(75) | 20-25 |
Cyclacillin | Semisynthetic | Good | No | Broad | Good | 20-25 |
Carbenicillin | Semisynthetic | Poor | No | Extended | Nill | 50-60 |
Ticarcillin | Semisynthetic | Poor | No | Extended | Nill | 45 |
Azlocillin | Semisynthetic | Poor | No | Extended | Nill | 20 |
Mwzlocillin | Semisynthetic | Poor | No | Extended | Nill | 50 |
Piperacillin | Semisynthetic | Poor | No | Extended | Nill | 50 |
補充 口服生體可用率最高是amoxicillin
